Characters like Sorceresses will often use this trick to kill Mephisto easily and quickly. I loaded up the game and did one quick search on Hell difficulty, traveling clockwise, hugging the wall(s): These maps are generated randomly, so learning a few map layouts will not help you. Depending on who you ask, you either search the map clockwise or counterclockwise. Here is one of many charts which you can find online to show you where you gain the most benefits from Faster Cast Rate, with an explanation here. Items like Wizardspike give this benefit. A player with multiple items giving Faster Cast Rate can cast Teleport very quickly, and as a result, cover more ground quicker while searching for the next level. This is either a skill that a Sorceress will level up in her skill tree, or a skill gained by an item such as Enigma runeword armor.
Legitimately fast Mephisto runs are the result of a few things:
